The question that has been formulated and researched is: for patients, who are on mechanical ventilation, does the use of ventilator bundle, with an examination of critical care nurses’ knowledge on the ventilator bundle, an effective prevention technique for VAP? The paper discusses how EBP can be incorporated into practice and the leadership model was drawn up to implement and supervise EBP.Ventilator-associated pneumonia continues to be a major threat to patient safety. It is a huge challenge to critical care practitioners since it has become a leading cause of death among hospital-acquired infections. Ventilator-associated pneumonia is a type of hospital-acquired pneumonia that occurs with mechanically-ventilated patients. It has become one of the respiratory infections that have received a lot of attention by experts over the past years, and because of the high rate of mortality that it causes, studies have focused on preventative measures. However, despite the number of studies that have been conducted on VAP, the results of the studies vary widely. As a result, the knowledge of nurses about preventative measures also varied widely. The assessment of knowledge that critical care nurses had regarding preventative measures, particularly the use of ventilator bundles, is important since the better-informed the nurses are, the better their performance will be. Since the VAP is a leading cause of death in hospital-acquired infections, nurses must have awareness of the protocol and incorporate it into practice to reduce the chances of death in mechanically-ventilated patients due to respiratory infections.The problem arose in intensive care units, where patients receive critical care. It is the patients who are directly affected by the problem. however, it needs to be noted that if the mortality rate of the hospital is low, and proper measures are being taken to prevent thepatients from getting VAP, it would reflect positively on the practice of the nurses and the reputation of the hospital.